Recombinant Human Endothelin-3 (EDN3), Homo sapiens (Human), Yeast, C-terminal 6xHis-Myc-tagged, 7.0kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Endothelin-3 (EDN3)

Recombinant Human Endothelin-3 (EDN3) — recombinant protein from Homo sapiens (Human), expressed in Yeast. Purity >85%.

SKU: BCRECP-000558 Category:
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Product Specifications

Product SkuBCRECP-000558
Product DescriptionRecombinant Human Endothelin-3 (EDN3) Protein is expressed from Yeast with C-terminal 6xHis-Myc-tagged. It contains 97-117aa. [Accession | P14138].
Uniprot No.P14138
Gene NamesEDN3
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region97-117aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-Myc-tagged
Molecular weight7.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Endothelins are endothelium-derived vasoconstrictor peptides.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells
Disease Association: Hirschsprung disease 4 (HSCR4) : A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child. [The disease is caused by variants affecting the gene represented in this entry] | Waardenburg syndrome 4B (WS4B) : A disorder characterized by the association of Waardenburg features (depigmentation and deafness) with the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Endothelin-3 (EDN3) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 97-117aa, with C-terminal 6xHis-Myc-tagged tag, molecular weight 7.0kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Endothelins are endothelium-derived vasoconstrictor peptides

Subcellular Location

Secreted

Disease Association

Hirschsprung disease 4 (HSCR4) : A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child. [The disease is caused by variants affecting the gene represented in this entry] | Waardenburg syndrome 4B (WS4B) : A disorder characterized by the association of Waardenburg features (depigmentation and deafness) with the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells

Gene: EDN3  |  Organism: Homo sapiens  |  Synonyms: Preproendothelin-3

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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