Recombinant Human Fidgetin-like protein 1 (FIGNL1), partial, Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged, 37.1kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Fidgetin-like protein 1 (FIGNL1), partial

Recombinant Human Fidgetin-like protein 1 (FIGNL1), partial — ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR). Purity >85%.

SKU: BCRECP-000676 Category:
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Product Specifications

Product SkuBCRECP-000676
Product DescriptionRecombinant Human Fidgetin-like protein 1 (FIGNL1) Protein is expressed from E.coli with N-terminal 10xHis-tagged. It contains 374-674aa. [Accession | Q6PIW4].
Uniprot No.Q6PIW4
Gene NamesFIGNL1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region374-674aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight37.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR). Regulates HR by mediating disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases. Also regulates HR during meiosis by mediating dissociation of DMC1 filaments from DNA.

Biological Context

Subcellular Location: Chromosome; Nucleus; Cytoplasm; Cytoplasm, perinuclear region
Disease Association: [Ovarian dysgenesis. An autosomal recessive form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, dysgenic ovaries and hypergonadotropic hypogonadism as a result of streak gonads. The disease is caused by variants affecting the gene represented in this entry ]

Product Specifications

Recombinant Human Fidgetin-like protein 1 (FIGNL1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 374-674aa, with N-terminal 10xHis-tagged tag, molecular weight 37.1kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:23754376, PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805, PubMed:38597669, PubMed:39636933, PubMed:41166468). Regulates HR by mediating disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases (PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805, PubMed:38597669, PubMed:39636933, PubMed:41166468). Also regulates HR during meiosis by mediating dissociation of DMC1 filaments from DNA (By similarity). May regulate osteoblast proliferation and differentiation (By similarity)

Subcellular Location

Chromosome; Nucleus; Cytoplasm; Cytoplasm, perinuclear region

Disease Association

[Ovarian dysgenesis (PubMed:37740949). An autosomal recessive form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, dysgenic ovaries and hypergonadotropic hypogonadism as a result of streak gonads (PubMed:37740949). The disease is caused by variants affecting the gene represented in this entry (PubMed:37740949)]

Subunit

Hexamer; can dissociate RAD51 and DMC1 filments when assembled into a hexamer (PubMed:39636933, PubMed:41166468). Interacts with FIRRM; forming the FIGNL1-FIRRM complex, which regulates homologous recombination (PubMed:29608566, PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805). Interacts (via FRBD region) with RAD51; the interaction is direct and promotes dissociation of RAD51 nucleoprotein filaments (PubMed:23754376, PubMed:39636933, PubMed:41166468). Interacts (via FRBD region) with DMC1; the interaction is direct and promotes dissociation of DMC1 nucleoprotein filaments (By similarity). Interacts (via N-terminal one-half region) with SPIDR (via the C-terminal region); the interaction is direct (PubMed:23754376)

Gene: FIGNL1  |  Organism: Homo sapiens

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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