Recombinant Human Follicle-stimulating hormone receptor (FSHR), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 44.0kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Follicle-stimulating hormone receptor (FSHR), partial

Recombinant Human Follicle-stimulating hormone receptor (FSHR), partial — G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Purity >90%.

SKU: BCRECP-000696 Category:
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Product Specifications

Product SkuBCRECP-000696
Product DescriptionRecombinant Human Follicle-stimulating hormone receptor (FSHR) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 18-366aa. [Accession | P23945].
Uniprot No.P23945
Gene NamesFSHR
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region18-366aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight44.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Sertoli cells and ovarian granulosa cells
Disease Association: Ovarian dysgenesis 1 (ODG1) : An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). [The disease is caused by variants affecting the gene represented in this entry] | Ovarian hyperstimulation syndrome (OHSS) : Disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Follicle-stimulating hormone receptor (FSHR), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 18-366aa, with N-terminal 6xHis-tagged tag, molecular weight 44.0kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690)

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Disease Association

Ovarian dysgenesis 1 (ODG1) : An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). [The disease is caused by variants affecting the gene represented in this entry] | Ovarian hyperstimulation syndrome (OHSS) : Disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Sertoli cells and ovarian granulosa cells

Subunit

Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (PubMed:24692546). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation (PubMed:17030088)

Gene: FSHR  |  Organism: Homo sapiens  |  Synonyms: Follitropin receptor
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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