Recombinant Human Gamma-aminobutyric acid receptor subunit pi (GABRP), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 28.9kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Gamma-aminobutyric acid receptor subunit pi (GABRP), partial

Recombinant Human Gamma-aminobutyric acid receptor subunit pi (GABRP), partial — Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA). Purity >85%.

SKU: BCRECP-000722 Category:
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Product Specifications

Product SkuBCRECP-000722
Product DescriptionRecombinant Human Gamma-aminobutyric acid receptor subunit pi (GABRP) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 17-242aa. [Accession | O00591].
Uniprot No.O00591
Gene NamesGABRP
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region17-242aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight28.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein); Apical cell membrane (Multi-pass membrane protein)
Tissue Specificity: Most abundant in non-neuronal tissues including the uterus, ovaries and also expressed in lung, thymus and prostate. Expressed in the hippocampus

Product Specifications

Recombinant Human Gamma-aminobutyric acid receptor subunit pi (GABRP), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 17-242aa, with N-terminal 6xHis-tagged tag, molecular weight 28.9kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA) (PubMed:10462548). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10462548). Pi-containing GABAARs are mostly located in peripheral tissues. In the uterus, pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone (PubMed:9182563). In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride (By similarity)

Subcellular Location

Cell membrane (Multi-pass membrane protein); Apical cell membrane (Multi-pass membrane protein)

Tissue Specificity

Most abundant in non-neuronal tissues including the uterus, ovaries and also expressed in lung, thymus and prostate (PubMed:10462548, PubMed:9182563). Expressed in the hippocampus (PubMed:10462548)

Subunit

Heteropentamer, formed by a combination of alpha (GABRA1-6), beta (GABRB1-3), gamma (GABRG1-3), delta (GABRD), epsilon (GABRE), rho (GABRR1-3), pi (GABRP) and theta (GABRQ) chains, each subunit exhibiting distinct physiological and pharmacological properties

Gene: GABRP  |  Organism: Homo sapiens  |  Synonyms: GABA(A) receptor subunit pi

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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