Recombinant Human Neuron-specific calcium-binding protein hippocalcin (HPCA), Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 29.7kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Neuron-specific calcium-binding protein hippocalcin (HPCA)

Recombinant Human Neuron-specific calcium-binding protein hippocalcin (HPCA) — Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. Purity >90%.

SKU: BCRECP-000853 Category:
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Product Specifications

Product SkuBCRECP-000853
Product DescriptionRecombinant Human Neuron-specific calcium-binding protein hippocalcin (HPCA) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 2-193aa. [Accession | P84074].
Uniprot No.P84074
Gene NamesHPCA
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-193aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight29.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases.

Biological Context

Subcellular Location: Cytoplasm, cytosol; Membrane (Peripheral membrane protein)
Tissue Specificity: Brain specific
Disease Association: Dystonia 2, torsion, autosomal recessive (DYT2) : A form of torsion dystonia, a disease defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. 'Torsion' refers to the twisting nature of body movements, often affecting the trunk. DYT2 is a slowly progressive form that first affects distal limbs and later involves the neck, orofacial, and craniocervical regions. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Neuron-specific calcium-binding protein hippocalcin (HPCA) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-193aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 29.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity)

Subcellular Location

Cytoplasm, cytosol; Membrane (Peripheral membrane protein)

Disease Association

Dystonia 2, torsion, autosomal recessive (DYT2) : A form of torsion dystonia, a disease defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. 'Torsion' refers to the twisting nature of body movements, often affecting the trunk. DYT2 is a slowly progressive form that first affects distal limbs and later involves the neck, orofacial, and craniocervical regions. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Brain specific

Subunit

Oligomer; oligomerization is calcium-dependent (PubMed:28398555). May interact with the voltage-dependent P/Q- and N-type calcium channels CACNA1A and CACNA1B (PubMed:28398555)

Gene: HPCA  |  Organism: Homo sapiens  |  Synonyms: Calcium-binding protein BDR-2
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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