Recombinant Human Hyaluronidase-2 (HYAL2), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 51.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Hyaluronidase-2 (HYAL2)

Recombinant Human Hyaluronidase-2 (HYAL2) — Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases. Purity >90%.

SKU: BCRECP-000874 Category:
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Product Specifications

Product SkuBCRECP-000874
Product DescriptionRecombinant Human Hyaluronidase-2 (HYAL2) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 21-448aa. [Accession | Q12891].
Uniprot No.Q12891
Gene NamesHYAL2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region21-448aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight51.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases. Essential for the breakdown of extracellular matrix hyaluronan.

Biological Context

Subcellular Location: Cell membrane (Lipid-anchor, GPI-anchor)
Tissue Specificity: Widely expressed (at protein level)
Disease Association: Muggenthaler-Chowdhury-Chioza syndrome (MCCS) : An autosomal recessive disorder characterized by distinctive craniofacial dysmorphism with frontal bossing, hypertelorism, a broad and flattened nasal tip, and cupped ears with superior helices. Other common but variable clinical manifestations are unilateral or bilateral cleft lip and palate, congenital cardiac anomalies, ocular features including mild to severe myopia and cataracts, single palmar crease, and pectus excavatum. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Hyaluronidase-2 (HYAL2) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 21-448aa, with N-terminal 6xHis-tagged tag, molecular weight 51.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases (PubMed:9712871). Essential for the breakdown of extracellular matrix hyaluronan (PubMed:28081210)

Subcellular Location

Cell membrane (Lipid-anchor, GPI-anchor)

Disease Association

Muggenthaler-Chowdhury-Chioza syndrome (MCCS) : An autosomal recessive disorder characterized by distinctive craniofacial dysmorphism with frontal bossing, hypertelorism, a broad and flattened nasal tip, and cupped ears with superior helices. Other common but variable clinical manifestations are unilateral or bilateral cleft lip and palate, congenital cardiac anomalies, ocular features including mild to severe myopia and cataracts, single palmar crease, and pectus excavatum. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Widely expressed (at protein level)

Subunit

Interacts with MST1R

Gene: HYAL2  |  Organism: Homo sapiens  |  Synonyms: Hyaluronoglucosaminidase-2; Lung carcinoma protein 2
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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