Recombinant Human Leukemia inhibitory factor receptor (LIFR), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-Flag-tagged, 119.3kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Leukemia inhibitory factor receptor (LIFR), partial (Active)

Recombinant Human Leukemia inhibitory factor receptor (LIFR), partial (Active) — recombinant protein from Homo sapiens (Human), expressed in Mammalian cell. Purity >95%.

SKU: BCRECP-001071 Category:
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Product Specifications

Product SkuBCRECP-001071
Product DescriptionRecombinant Human Leukemia inhibitory factor receptor (LIFR) Protein is expressed from Mammalian cell with C-terminal hFc1-Flag-tagged. It contains 45-833aa. [Accession | P42702].
Uniprot No.P42702
Gene NamesLIFR
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region45-833aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-Flag-tagged
Molecular weight119.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Could inhibit the biological activity of LIF by blocking its binding to receptors on target cells.

Biological Context

Subcellular Location: Secreted
Disease Association: Stuve-Wiedemann syndrome 1 (STWS1) : A form of Stuve-Wiedemann syndrome, an autosomal recessive disease characterized by bowing of tubular bones and other skeletal and craniofacial abnormalities, respiratory distress, feeding difficulties, and hyperthermic episodes. Most patients do not survive past infancy. [The disease is caused by variants affecting the gene represented in this entry] | [A chromosomal aberration involving LIFR is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1]

Product Specifications

Recombinant Human Leukemia inhibitory factor receptor (LIFR), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 45-833aa, with C-terminal hFc1-Flag-tagged tag, molecular weight 119.3kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Could inhibit the biological activity of LIF by blocking its binding to receptors on target cells

Subcellular Location

Secreted

Disease Association

Stuve-Wiedemann syndrome 1 (STWS1) : A form of Stuve-Wiedemann syndrome, an autosomal recessive disease characterized by bowing of tubular bones and other skeletal and craniofacial abnormalities, respiratory distress, feeding difficulties, and hyperthermic episodes. Most patients do not survive past infancy. [The disease is caused by variants affecting the gene represented in this entry] | [A chromosomal aberration involving LIFR is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1]

Subunit

Heterodimer composed of LIFR and IL6ST (PubMed:1542794). Component of the ciliary neurotrophic factor receptor (CNTFR) complex composed of CNTFR, LIFR and IL6ST; CNTF binding to CNTFR induces heterodimerization of LIFR and IL6ST (PubMed:18775332, PubMed:36930708)

Gene: LIFR  |  Organism: Homo sapiens
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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