Recombinant Human Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C), Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged, 20.7kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C)

Recombinant Human Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) — Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Purity >85%.

SKU: BCRECP-001120 Category:
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Product Specifications

Product SkuBCRECP-001120
Product DescriptionRecombinant Human Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) Protein is expressed from E.coli with N-terminal 10xHis-tagged. It contains 1-126aa. [Accession | Q9BXW4].
Uniprot No.Q9BXW4
Gene NamesMAP1LC3C
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-126aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight20.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins.

Biological Context

Subcellular Location: Cytoplasmic vesicle, autophagosome membrane (Lipid-anchor); Endomembrane system (Lipid-anchor); Cytoplasm, cytoskeleton
Tissue Specificity: Most abundant in placenta, lung and ovary

Product Specifications

Recombinant Human Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-126aa, with N-terminal 10xHis-tagged tag, molecular weight 20.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2 (PubMed:23022382). Recruits all ATG8 family members to infecting bacteria such as S.typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643)

Subcellular Location

Cytoplasmic vesicle, autophagosome membrane (Lipid-anchor); Endomembrane system (Lipid-anchor); Cytoplasm, cytoskeleton

Tissue Specificity

Most abundant in placenta, lung and ovary

Subunit

3 different light chains, LC1 (a cleavage product of MAP1B), LC2 (a cleavage product of MAP1A) and LC3 (produced by one of the MAP1LC3 genes), can associate with the MAP1A or MAP1B heavy chains (By similarity). Interacts with TP53INP1 and TP53INP2 (PubMed:22470510). Interacts with CALCOCO2 (PubMed:23022382). Interacts with TECPR2 (PubMed:20562859). Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2 (PubMed:20529957). Interacts with UBQLN4 (via STI1 1 and 2 domains) (PubMed:23459205). Interacts with UBQLN1 in the presence of UBQLN4 (PubMed:23459205). Interacts with TRIM5 (PubMed:25127057). Interacts with ATG13 (PubMed:24290141). Interacts with MEFV and TRIM21 (PubMed:26347139). Interacts with WDR81; recruits MAP1LC3C to ubiquitinated protein aggregates in the aggrephagy process (PubMed:28404643). Interacts with MOAP1 (via LIR motif) (PubMed:33783314). Interacts with reticulophagy regulators RETREG1, RETREG2 and RETREG3 (PubMed:34338405). Interacts with TAX1BP1 (PubMed:26451915). Interacts with IRGM (PubMed:29420192). Interacts with SPART (PubMed:37443287). Interacts with UBAC2 (PubMed:39284914)

Gene: MAP1LC3C  |  Organism: Homo sapiens  |  Synonyms: Autophagy-related protein LC3 C; Autophagy-related ubiquitin-like modifier LC3 C; MAP1 light chain 3-like protein 3; Microtubule-associated proteins 1A/1B light chain 3C
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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