Recombinant Human Membrane-associated progesterone receptor component 2 (PGRMC2), Partial, Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 24.8kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Membrane-associated progesterone receptor component 2 (PGRMC2), Partial

Recombinant Human Membrane-associated progesterone receptor component 2 (PGRMC2), Partial — Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Purity >85%.

SKU: BCRECP-001377 Category:
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Product Specifications

Product SkuBCRECP-001377
Product DescriptionRecombinant Human Membrane-associated progesterone receptor component 2 (PGRMC2) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 67-223aa. [Accession | O15173].
Uniprot No.O15173
Gene NamesPGRMC2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region67-223aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight24.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus.

Biological Context

Subcellular Location: Membrane (Single-pass membrane protein); Nucleus envelope; Endoplasmic reticulum; Secreted
Tissue Specificity: Expressed by endometrial glands and stroma (at protein level). Detected in urine (at protein level)

Product Specifications

Recombinant Human Membrane-associated progesterone receptor component 2 (PGRMC2), Partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 67-223aa, with C-terminal 6xHis-tagged tag, molecular weight 24.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity)

Subcellular Location

Membrane (Single-pass membrane protein); Nucleus envelope; Endoplasmic reticulum; Secreted

Tissue Specificity

Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472). Detected in urine (at protein level) (PubMed:37453717)

Subunit

Interacts with PGRMC1 (By similarity). Interacts with AAAS (PubMed:27754849)

Gene: PGRMC2  |  Organism: Homo sapiens  |  Synonyms: Progesterone membrane-binding protein; Steroid receptor protein DG6
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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