Recombinant Human S-arrestin (SAG), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 47.1kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human S-arrestin (SAG)

Recombinant Human S-arrestin (SAG) — Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G proteins by competing with G proteins for the same binding site on RHO. Purity >90%.

SKU: BCRECP-001578 Category:
Online Inquiry →

Product Specifications

Product SkuBCRECP-001578
Product DescriptionRecombinant Human S-arrestin (SAG) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 1-405aa. [Accession | P10523].
Uniprot No.P10523
Gene NamesSAG
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-405aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight47.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G proteins by competing with G proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.

Biological Context

Subcellular Location: Cell projection, cilium, photoreceptor outer segment; Membrane (Peripheral membrane protein)
Tissue Specificity: Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level)
Disease Association: Night blindness, congenital stationary, Oguchi type 1 (CSNBO1) : A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation. [The disease is caused by variants affecting the gene represented in this entry] | Retinitis pigmentosa 47 (RP47) : A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. [The disease is caused by variants affecting the gene represented in this entry] | Retinitis pigmentosa 96 (RP96) : An autosomal dominant form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human S-arrestin (SAG) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-405aa, with N-terminal 6xHis-tagged tag, molecular weight 47.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G proteins by competing with G proteins for the same binding site on RHO (By similarity). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049)

Subcellular Location

Cell projection, cilium, photoreceptor outer segment; Membrane (Peripheral membrane protein)

Disease Association

Night blindness, congenital stationary, Oguchi type 1 (CSNBO1) : A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation. [The disease is caused by variants affecting the gene represented in this entry] | Retinitis pigmentosa 47 (RP47) : A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. [The disease is caused by variants affecting the gene represented in this entry] | Retinitis pigmentosa 96 (RP96) : An autosomal dominant form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level)

Subunit

Monomer. Homodimer. Homotetramer (PubMed:21288033). Interacts with RHO (via the phosphorylated C-terminus) (PubMed:26200343, PubMed:28753425)

Gene: SAG  |  Organism: Homo sapiens  |  Synonyms: 48 kDa protein; Retinal S-antigen; Rod photoreceptor arrestin
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

Shopping Cart
Scroll to Top