Recombinant Human Sodium/iodide cotransporter (SLC5A5), partial, Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 17.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Sodium/iodide cotransporter (SLC5A5), partial

Recombinant Human Sodium/iodide cotransporter (SLC5A5), partial — Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland. Purity >90%.

SKU: BCRECP-001657 Category:
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Product Specifications

Product SkuBCRECP-001657
Product DescriptionRecombinant Human Sodium/iodide cotransporter (SLC5A5) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 547-643aa. [Accession | Q92911].
Uniprot No.Q92911
Gene NamesSLC5A5
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region547-643aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight17.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland. Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein); Cytoplasm
Tissue Specificity: Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors
Disease Association: Thyroid dyshormonogenesis 1 (TDH1) : A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Sodium/iodide cotransporter (SLC5A5), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 547-643aa, with C-terminal 6xHis-tagged tag, molecular weight 17.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:20797386, PubMed:31310151, PubMed:32084174, PubMed:8806637, PubMed:9329364). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351)

Subcellular Location

Cell membrane (Multi-pass membrane protein); Cytoplasm

Disease Association

Thyroid dyshormonogenesis 1 (TDH1) : A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors

Subunit

Monomer

Gene: SLC5A5  |  Organism: Homo sapiens  |  Synonyms: Natrium iodide transporter; Sodium-iodide symporter; Solute carrier family 5 member 5
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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