Recombinant Human Zinc finger protein ZPR1 (ZPR1), Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 58.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Zinc finger protein ZPR1 (ZPR1)

Recombinant Human Zinc finger protein ZPR1 (ZPR1) — Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Purity >90%.

SKU: BCRECP-001944 Category:
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Product Specifications

Product SkuBCRECP-001944
Product DescriptionRecombinant Human Zinc finger protein ZPR1 (ZPR1) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1-459aa. [Accession | O75312].
Uniprot No.O75312
Gene NamesZPR1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-459aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight58.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies.

Biological Context

Subcellular Location: Nucleus; Nucleus, nucleolus; Nucleus, gem; Nucleus, Cajal body; Cytoplasm, perinuclear region; Cytoplasm; Cell projection, axon; Cell projection, growth cone
Tissue Specificity: Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients
Disease Association: Growth restriction, hypoplastic kidneys, alopecia, and distinctive facies (GKAF) : An autosomal recessive disorder characterized by pre- and postnatal growth restriction with microcephaly, distinctive craniofacial features, congenital alopecia, hypoplastic kidneys with renal insufficiency, global developmental delay, severe congenital sensorineural hearing loss, hydrocephalus, genital hypoplasia, and early mortality. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Zinc finger protein ZPR1 (ZPR1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-459aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 58.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression (PubMed:29851065). Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death

Subcellular Location

Nucleus; Nucleus, nucleolus; Nucleus, gem; Nucleus, Cajal body; Cytoplasm, perinuclear region; Cytoplasm; Cell projection, axon; Cell projection, growth cone

Disease Association

Growth restriction, hypoplastic kidneys, alopecia, and distinctive facies (GKAF) : An autosomal recessive disorder characterized by pre- and postnatal growth restriction with microcephaly, distinctive craniofacial features, congenital alopecia, hypoplastic kidneys with renal insufficiency, global developmental delay, severe congenital sensorineural hearing loss, hydrocephalus, genital hypoplasia, and early mortality. [The disease may be caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients

Subunit

Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C-terminal region); the interaction occurs after treatment with serum. Interacts with elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and the EGFR kinase activity. May also bind to the PDGFR receptor

Gene: ZPR1  |  Organism: Homo sapiens  |  Synonyms: Zinc finger protein 259
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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