Recombinant Macaca mulatta Microtubule-associated protein tau (MAPT) (Active), Macaca mulatta (Rhesus macaque), Mammalian cell, N-terminal 10xHis-tagged, 50.6kDa, purity >95% as determined by SDS-PAGE.

Recombinant Macaca mulatta Microtubule-associated protein tau (MAPT) (Active)

Recombinant Macaca mulatta Microtubule-associated protein tau (MAPT) (Active) — Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Purity >95%.

SKU: BCRECP-003349 Category:
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Product Specifications

Product SkuBCRECP-003349
Product DescriptionRecombinant Macaca mulatta Microtubule-associated protein tau (MAPT) (Active) Protein is expressed from Mammalian cell with N-terminal 10xHis-tagged. It contains 2-459aa. [Accession | P57786].
Uniprot No.P57786
Gene NamesMAPT
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region2-459aa
SpeciesMacaca mulatta (Rhesus macaque)
Tag InfoN-terminal 10xHis-tagged
Molecular weight50.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome.

Biological Context

Subcellular Location: Cytoplasm, cytosol; Cell membrane (Peripheral membrane protein); Cytoplasm, cytoskeleton; Cell projection, axon; Cell projection, dendrite; Secreted
Tissue Specificity: Expressed in neurons

Product Specifications

Recombinant Macaca mulatta Microtubule-associated protein tau (MAPT) (Active) is a recombinant protein from Macaca mulatta (Rhesus macaque), expressed in Mammalian cell, covering amino acids 2-459aa, with N-terminal 10xHis-tagged tag, molecular weight 50.6kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization

Subcellular Location

Cytoplasm, cytosol; Cell membrane (Peripheral membrane protein); Cytoplasm, cytoskeleton; Cell projection, axon; Cell projection, dendrite; Secreted

Tissue Specificity

Expressed in neurons

Subunit

Interacts with MARK1, MARK2, MARK3 and MARK4 (By similarity). Interacts with SQSTM1 when polyubiquitinated (By similarity). Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with FKBP4 (By similarity). Binds to CSNK1D (By similarity). Interacts with SGK1 (By similarity). Interacts with PIN1 (By similarity). Interacts with LRRK2 (By similarity). Interacts with LRP1, leading to endocytosis; this interaction is reduced in the presence of LRPAP1/RAP (By similarity)

Gene: MAPT  |  Organism: Macaca mulatta  |  Synonyms: Neurofibrillary tangle protein; Paired helical filament-tau

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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