Recombinant Human IL23 23-328aa (IL12B) / 20-189aa (IL23A) Protein, Baculovirus-Insect Cells, N-6His, 34.6kDa (IL12B) & 19.5kDa (IL23A) (306aa & 176aa), purity >90% as determined by SDS-PAGE.

Recombinant Human IL23 23-328aa (IL12B) / 20-189aa (IL23A) Protein

Recombinant Human IL23 23-328aa (IL12B) / 20-189aa (IL23A) Protein — Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. Purity >90%.

SKU: BCRETP-000020 Category:
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Product Specifications

Product SkuBCRETP-000020
Product DescriptionRecombinant Human IL23 23-328aa (IL12B) / 20-189aa (IL23A) Protein is expressed from Baculovirus-Insect Cells with His tag at the N-Terminus. It contains 23-328aa/20-189aa. [Accession | P29460；Q9NPF7].
Uniprot No.P29460；Q9NPF7
SynonymsInterleukin-12 subunit beta / Interleukin-23 subunit alpha, CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2/ IL-23, IL-23A, IL23P19, P19, SGRF
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemBaculovirus-Insect Cells
Expression Region23-328aa/20-189aa
Tag InfoN-6His
Molecular weight34.6kDa (IL12B) & 19.5kDa (IL23A) (306aa & 176aa)
EndotoxinLess than 1.0 EU/μg as determined by LAL method.

Function

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines.

Product Specifications

Recombinant Human IL23 23-328aa (IL12B) / 20-189aa (IL23A) Protein is a recombinant protein, expressed in Baculovirus-Insect Cells, covering amino acids 23-328aa/20-189aa, with N-6His tag, molecular weight 34.6kDa (IL12B) & 19.5kDa (IL23A) (306aa & 176aa), purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis

Gene: IL12B  |  Organism: Homo sapiens

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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