Recombinant Dendroaspis angusticeps Natriuretic peptide DNP, Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps), E.coli, N-terminal 6xHis-KSI-tagged, 19.5kDa, purity >85% as determined by SDS-PAGE.

Recombinant Dendroaspis angusticeps Natriuretic peptide DNP

Recombinant Dendroaspis angusticeps Natriuretic peptide DNP — Exhibits vasodilator, natriuretic and diuretic properties in animal models and human tissues. Purity >85%.

SKU: BCRECP-003621 Category:
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Product Specifications

Product SkuBCRECP-003621
Product DescriptionRecombinant Dendroaspis angusticeps Natriuretic peptide DNP Protein is expressed from E.coli with N-terminal 6xHis-KSI-tagged. It contains 1-38aa. [Accession | P28374].
Uniprot No.P28374
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-38aa
SpeciesDendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Tag InfoN-terminal 6xHis-KSI-tagged
Molecular weight19.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Exhibits vasodilator, natriuretic and diuretic properties in animal models and human tissues. Acts by stimulating cGMP via the natriuretic peptide receptor 1 (NPR1). Is a poor agonist of the atrial natriuretic peptide receptor 2 (NPR2).

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed by the venom gland

Product Specifications

Recombinant Dendroaspis angusticeps Natriuretic peptide DNP is a recombinant protein from Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps), expressed in E.coli, covering amino acids 1-38aa, with N-terminal 6xHis-KSI-tagged tag, molecular weight 19.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Exhibits vasodilator, natriuretic and diuretic properties in animal models and human tissues. Acts by stimulating cGMP via the natriuretic peptide receptor 1 (NPR1) (PubMed:16778132). Is a poor agonist of the atrial natriuretic peptide receptor 2 (NPR2). Is not degraded by neutral endopeptidase (NEP/MME). Binds to atrial natriuretic peptide clearance receptor (NPR-C/NPR3), which may be responsible of the removal of DNP from the circulation (PubMed:17475216). Increases calcium uptake and induces histamine release from rat peritoneal mast cells. Increases calcium-activated potassium (KCa) current in gastric antral circular smooth muscle cells by increasing cGMP production and activating inositol trisphosphate receptors (IP3Rs) (PubMed:18096107). In vivo, reduces both systolic and diastolic blood pressure with no effect on heart rate, when intravenously injected in conscious rabbits (PubMed:37049825)

Subcellular Location

Secreted

Tissue Specificity

Expressed by the venom gland

Organism: Dendroaspis angusticeps
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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