Recombinant Mouse Spectrin beta chain, non-erythrocytic 1 (Sptbn1), partial, Mus musculus (Mouse), Yeast, C-terminal 6xHis-tagged, 13.8kDa, purity >95% as determined by SDS-PAGE.

Recombinant Mouse Spectrin beta chain, non-erythrocytic 1 (Sptbn1), partial

Recombinant Mouse Spectrin beta chain, non-erythrocytic 1 (Sptbn1), partial — Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Purity >95%.

SKU: BCRECP-004481 Category:
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Product Specifications

Product SkuBCRECP-004481
Product DescriptionRecombinant Mouse Spectrin beta chain, non-erythrocytic 1 (Sptbn1) Protein is expressed from Yeast with C-terminal 6xHis-tagged. It contains 2199-2304aa. [Accession | Q62261].
Uniprot No.Q62261
Gene NamesSptbn1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region2199-2304aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal 6xHis-tagged
Molecular weight13.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function.

Biological Context

Subcellular Location: Cytoplasm; Cell membrane (Peripheral membrane protein)
Tissue Specificity: Isoform 2 is present in brain, heart, kidney and liver (at protein level)

Product Specifications

Recombinant Mouse Spectrin beta chain, non-erythrocytic 1 (Sptbn1), partial is a recombinant protein from Mus musculus (Mouse), expressed in Yeast, covering amino acids 2199-2304aa, with C-terminal 6xHis-tagged tag, molecular weight 13.8kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function

Subcellular Location

Cytoplasm; Cell membrane (Peripheral membrane protein)

Tissue Specificity

Isoform 2 is present in brain, heart, kidney and liver (at protein level)

Subunit

Interacts with ANK2 (PubMed:15262991). Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers (By similarity). Interacts with CAMSAP1 (By similarity). Can form heterodimers with SPTAN1

Gene: Sptbn1  |  Organism: Mus musculus  |  Synonyms: Beta-II spectrin; Embryonic liver fodrin; Fodrin beta chain
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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