Recombinant Mouse Zinc finger protein 410 (Znf410), Mus musculus (Mouse), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 59.7kDa, purity >85% as determined by SDS-PAGE.

Recombinant Mouse Zinc finger protein 410 (Znf410)

Recombinant Mouse Zinc finger protein 410 (Znf410) — Transcription factor that binds to the sequence motif 5′-CATCCCATAATA-3′, and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells. Purity >85%.

SKU: BCRECP-004785 Category:
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Product Specifications

Product SkuBCRECP-004785
Product DescriptionRecombinant Mouse Zinc finger protein 410 (Znf410) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1-478aa. [Accession | Q8BKX7].
Uniprot No.Q8BKX7
Gene NamesZnf410
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-478aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight59.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells. Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells. May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.

Biological Context

Subcellular Location: Nucleus; Chromosome

Product Specifications

Recombinant Mouse Zinc finger protein 410 (Znf410) is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 1-478aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 59.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416). Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416). May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (By similarity). May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (By similarity). However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (By similarity)

Subcellular Location

Nucleus; Chromosome

Subunit

Interacts with CDKN2A/p14ARF

Gene: Znf410  |  Organism: Mus musculus  |  Synonyms: Another partner for ARF 1

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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