Mouse anti-Human/Mouse/Rat KRT16 Monoclonal Antibody

Function

Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance

Disease Association

Pachyonychia congenita 1 (PC1) : An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present. [The disease is caused by variants affecting the gene represented in this entry] | Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1) : A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present. [The disease is caused by variants affecting the gene represented in this entry] | [KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris]

Tissue Specificity

Expressed in the corneal epithelium (at protein level)

Subunit

Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers (KRT6A or KRT6B) (By similarity). Interacts with TCHP (PubMed:15731013). Interacts with TRADD (By similarity)

• Raychaudhury A. et al. Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes. — Mol. Cell. Biol. (1986)
• Rosenberg M. et al. A group of type I keratin genes on human chromosome 17: characterization and expression. — Mol. Cell. Biol. (1988)
• Paladini R.D. et al. cDNA cloning and bacterial expression of the human type I keratin 16. — Biochem. Biophys. Res. Commun. (1995)
• Smith F.J.D. et al. Cloning of multiple keratin 16 genes: genotype-phenotype correlation and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma. (APR-)
• Ota T. et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. — Nat. Genet. (2004)
• Mural R.J. et al. PubMed: CI-5GBDQ6B103N1E (JUL-)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• McLean W.H.I. et al. Keratin 16 and keratin 17 mutations cause pachyonychia congenita. — Nat. Genet. (1995)