Mouse anti-Human/Mouse/Rat KRT8 Monoclonal Antibody
Mouse anti-Human/Mouse/Rat KRT8 Monoclonal Antibody - Image 2

Mouse anti-Human/Mouse/Rat KRT8 Monoclonal Antibody

Mouse anti-Human/Mouse/Rat KRT8 Monoclonal Antibody — Structural component of intermediate filaments in simple epithelial cells.

SKU: BCREC-000028MA Category:
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Product Specifications

Uniprot No.P05787
Target NamesKRT8
Species ReactivityMouse
ImmunogenSynthetic Peptide
ConjugateNon-conjugated
IsotypeIgG
ClonalityMonoclonal
ApplicationsELISA,WB,IHC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells. Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis.

Biological Context

Subcellular Location: Cytoplasm; Nucleus, nucleoplasm; Nucleus matrix; Cytoplasm, cytoskeleton
Tissue Specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity

Product Specifications

Mouse anti-Human/Mouse/Rat KRT8 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

Applications: ELISA,WB,IHC

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells (PubMed:26823019). Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis (By similarity). Also required for ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (PubMed:26823019). In striated muscle, together with KRT19, may contribute to linking the contractile apparatus to dystrophin at the costameres (PubMed:16000376)

Subcellular Location

Cytoplasm; Nucleus, nucleoplasm; Nucleus matrix; Cytoplasm, cytoskeleton

Tissue Specificity

Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity

Subunit

(Microbial infection) Interacts with hepatitis C virus/HCV core protein

Gene: KRT8  |  Organism: Homo sapiens  |  Synonyms: Cytokeratin-8; Keratin-8; Type-II keratin Kb8
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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