Mouse anti-Human/Mouse/Rat MAP2K2 Monoclonal Antibody

Function

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126)

Subcellular Location

Cytoplasm; Membrane (Peripheral membrane protein)

Disease Association

Cardiofaciocutaneous syndrome 4 (CFC4) : A form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and intellectual disability. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Interacts with MORG1 (By similarity). Interacts with SGK1 (PubMed:19447520). Interacts with KSR1 (PubMed:10409742). Interacts with KSR1 and BRAF; the interaction with KSR1 mediates KSR1-BRAF dimerization (PubMed:29433126). Interacts with GLS (PubMed:22538822)

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• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Bienvenut W.V. et al. PubMed: CI-43JDV6VDN1JOO (DEC-)
• Mittal R. et al. Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling. — Proc. Natl. Acad. Sci. U.S.A. (2006)
• Duesbery N.S. et al. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. — Science (1998)
• Stewart S. et al. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. — Mol. Cell. Biol. (1999)
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• Olsen J.V. et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. — Cell (2006)