Mouse anti-Human/Mouse/Rat NBR1 Monoclonal Antibody

Mouse anti-Human/Mouse/Rat NBR1 Monoclonal Antibody

Mouse anti-Human/Mouse/Rat NBR1 Monoclonal Antibody — Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis.

SKU: BCREC-000624MA Category:
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Product Specifications

Uniprot No.Q14596
Target NamesNBR1
Species ReactivityMouse
ImmunogenRecombinant Protein
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
ClonalityMonoclonal
ApplicationsELISA,IHC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation.

Biological Context

Subcellular Location: Cytoplasm; Cytoplasmic vesicle, autophagosome; Lysosome; Cytoplasm, myofibril, sarcomere, M line

Product Specifications

Mouse anti-Human/Mouse/Rat NBR1 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

Applications: ELISA,IHC

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133, PubMed:38169523). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity)

Subcellular Location

Cytoplasm; Cytoplasmic vesicle, autophagosome; Lysosome; Cytoplasm, myofibril, sarcomere, M line

Subunit

(Microbial infection) Interacts with Influenza A virus protein PB1; this interaction promotes NBR1-mediated selective autophagic degradation of MAVS

Gene: NBR1  |  Organism: Homo sapiens  |  Synonyms: Cell migration-inducing gene 19 protein; Membrane component chromosome 17 surface marker 2; Neighbor of BRCA1 gene 1 protein; Protein 1A1-3B
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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