Mouse anti-Human/Mouse/Rat PGR Monoclonal Antibody

Function

Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone

Subcellular Location

Mitochondrion outer membrane

Tissue Specificity

In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli

Subunit

Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2. Isoform A interacts with NCOR2. Isoform B (but not isoform A) interacts with NCOA2 and NCOA1. Isoform B (but not isoform A) interacts with KLF9. Interacts with GTF2B (PubMed:1517211)

• Kastner P. et al. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. — EMBO J. (1990)
• Misrahi M. et al. Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA. — Biochem. Biophys. Res. Commun. (1987)
• Kieback D.G. et al. PubMed: CI-4B8MBQ91HDQTN (JUL-)
• Hisatomi H. et al. Progesterone Receptor, alternative splicing variant, mRNA. (APR-)
• Chen C. et al. The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor. — Mol. Phylogenet. Evol. (2008)
• Saner K.J. et al. Cloning and expression of a novel, truncated, progesterone receptor. — Mol. Cell. Endocrinol. (2003)
• Ota T. et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. — Nat. Genet. (2004)
• PubMed: CI-86AL9GH7VDJIK (JAN-)