Mouse anti-Human/Mouse/Rat sapiens (Human) DDX50 Monoclonal Antibody
Mouse anti-Human/Mouse/Rat sapiens (Human) DDX50 Monoclonal Antibody - Image 2

Mouse anti-Human/Mouse/Rat sapiens (Human) DDX50 Monoclonal Antibody

Mouse anti-Human/Mouse/Rat sapiens (Human) DDX50 Monoclonal Antibody — ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production.

SKU: BCREC-000260MA Category:
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Product Specifications

Uniprot No.Q9BQ39
Target NamesDDX50
Species ReactivityMouse
ImmunogenRecombinant Human DDX50 protein
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
IsotypeMouse IgG2b
ClonalityMonoclonal
ApplicationsELISA, WB, ICC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production. Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses. For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection.

Biological Context

Subcellular Location: Nucleus, nucleolus; Cytoplasm
Tissue Specificity: Highest expression in skeletal muscle, liver, heart, placenta, and kidney

Product Specifications

Mouse anti-Human/Mouse/Rat sapiens (Human) DDX50 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

Applications: ELISA, WB, ICC

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908)

Subcellular Location

Nucleus, nucleolus; Cytoplasm

Tissue Specificity

Highest expression in skeletal muscle, liver, heart, placenta, and kidney

Subunit

Interacts with C1QBP. Interacts with the ubiquitin ligase CTLH complex through GID4 (PubMed:38773330). Interacts with TICAM1 (PubMed:35215908)

Gene: DDX50  |  Organism: Homo sapiens  |  Synonyms: DEAD box protein 50; Gu-beta; Nucleolar protein Gu2
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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