Mouse anti-Human/Mouse/Rat sapiens (Human) FERMT2 Monoclonal Antibody

Function

Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling

Subcellular Location

Cytoplasm; Cytoplasm, cell cortex; Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, stress fiber; Cell junction, focal adhesion; Membrane (Peripheral membrane protein); Cell projection, lamellipodium membrane (Peripheral membrane protein); Nucleus; Cytoplasm, myofibril, sarcomere, I band; Cell surface

Tissue Specificity

Ubiquitous. Found in numerous tumor tissues

Subunit

Interacts with ILK (By similarity). Interacts with FBLIM1. Interacts with ITGB1 and ITGB3. Interacts with active, unphosphorylated CTNNB1. Identified in a complex with CTNNB1 and TCF7L2/TCF4. Interacts with ITGB1; the interaction is inhibited in presence of ITGB1BP1

• Wick M. et al. Identification of serum-inducible genes: different patterns of gene regulation during G0->S and G1->S progression. — J. Cell Sci. (1994)
• Weinstein E.J. et al. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. — Biochim. Biophys. Acta (2003)
• Tu Y. et al. Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. — Cell (2003)
• Tan S.-M. et al. PubMed: CI-6RFVA409KGKCA (AUG-)
• Li W.B. et al. Full-length cDNA libraries and normalization. (JAN-)
• Heilig R. et al. The DNA sequence and analysis of human chromosome 14. — Nature (2003)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Ma Y.Q. et al. Kindlin-2 (Mig-2): a co-activator of beta3 integrins. — J. Cell Biol. (2008)