Mouse anti-Human/Mouse/Rat sapiens (Human) MAPRE2 Monoclonal Antibody

Function

Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684)

Subcellular Location

Cytoplasm, cytoskeleton

Disease Association

Skin creases, congenital symmetric circumferential, 2 (CSCSC2) : An autosomal dominant disease characterized by multiple, symmetric, circumferential rings of folded skin, affecting primarily the limbs. Affected individuals also exhibit intellectual disability, cleft palate, and dysmorphic features. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes

Subunit

Interacts with DCTN1. Interacts with APC (via C-terminal)(PubMed:14514668, PubMed:9233623). Interacts with monomeric and polymerized tubulin (PubMed:10188731, PubMed:14514668, PubMed:26637975). Interacts with SLAIN1 (PubMed:21646404). Interacts (via the N-terminal region) with BAG1 (PubMed:15986447). Interacts with ASB14 (By similarity). Interacts with HAX1; this interaction is essential for epidermal cell migration (PubMed:26527684)

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