Mouse anti-Human/Mouse/Rat sapiens (Human) UBE3A Monoclonal Antibody
Mouse anti-Human/Mouse/Rat sapiens (Human) UBE3A Monoclonal Antibody - Image 2
Mouse anti-Human/Mouse/Rat sapiens (Human) UBE3A Monoclonal Antibody - Image 3
Mouse anti-Human/Mouse/Rat sapiens (Human) UBE3A Monoclonal Antibody - Image 4

Mouse anti-Human/Mouse/Rat sapiens (Human) UBE3A Monoclonal Antibody

Mouse anti-Human/Mouse/Rat sapiens (Human) UBE3A Monoclonal Antibody — recombinant protein.

SKU: BCREC-000504MA Category:
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Product Specifications

Uniprot No.Q05086
Target NamesUBE3A
Species ReactivityMouse
ImmunogenRecombinant Human UBE3A protein
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
IsotypeMouse IgG1
ClonalityMonoclonal
ApplicationsELISA, WB, FC, ICC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

(Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses.

Biological Context

Subcellular Location: Cytoplasm; Nucleus
Disease Association: Angelman syndrome (AS) : A neurodevelopmental disorder characterized by severe motor and intellectual retardation, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, open-mouthed expression revealing the tongue. [The disease is caused by variants affecting the gene represented in this entry]
Pathway: Protein modification; protein ubiquitination

Product Specifications

Mouse anti-Human/Mouse/Rat sapiens (Human) UBE3A Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

Applications: ELISA, WB, FC, ICC

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

(Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses

Subcellular Location

Cytoplasm; Nucleus

Disease Association

Angelman syndrome (AS) : A neurodevelopmental disorder characterized by severe motor and intellectual retardation, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, open-mouthed expression revealing the tongue. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

(Microbial infection) Interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53/TP53 tumor-suppressor protein for ubiquitin-mediated proteolysis

Pathway

Protein modification; protein ubiquitination

Gene: UBE3A  |  Organism: Homo sapiens  |  Synonyms: E6AP ubiquitin-protein ligase; HECT-type ubiquitin transferase E3A; Human papillomavirus E6-associated protein; Oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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