Mouse anti-Human/Mouse/Rat sapiens (Human) YY1 Monoclonal Antibody

Function

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements

Subcellular Location

Nucleus matrix

Disease Association

Gabriele-de Vries syndrome (GADEVS) : An autosomal dominant neurodevelopmental disorder characterized by delayed psychomotor development and intellectual disability. Most patients have behavioral and feeding problems, movement abnormalities, mild distal skeletal anomalies, and dysmorphic facial features. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Interacts with YAF2 through the region encompassing the first and second zinc fingers (PubMed:9016636). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80 (PubMed:17721549, PubMed:18026119, PubMed:18922472, PubMed:21303910). Interacts with EED and EZH2; the interactions are indicative for an association with the PRC2/EED-EZH2 complex (PubMed:11158321). Interacts with SFMBT2 (PubMed:23385818). Found in a complex with SMAD1 and SMAD4 (PubMed:15329343). Found in a complex with YY1, SIN3A and HDAC1 (By similarity). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex, at least composed of BAP1, one of ASXL1, ASXL2 or (probably) ASXL3 and one of MBD5 or MBD6; the PR-DUB core associates with a number of accessory proteins, including FOXK1, FOXK2, KDM1B, HCFC1, YY1 and OGT (PubMed:20805357). Interacts (via Gly-rich region) with HCFC1; the interaction is direct (PubMed:20805357). Interacts (via C-terminal zinc-finger domains) with BAP1 (via ULD domain); the interaction is direct and requires HCFC1 (PubMed:20805357)

• Shi Y. et al. Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein. — Cell (1991)
• Park K. et al. Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. — Proc. Natl. Acad. Sci. U.S.A. (1991)
• Whitson R.H. et al. PubMed: CI-B2L6R9N3JI4JM (JUL-)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• McNeil S. et al. Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking. — J. Cell. Biochem. (1998)
• Kalenik J.L. et al. Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. — Nucleic Acids Res. (1997)
• Oei S.L. et al. Poly(ADP-ribosyl)ation of transcription factor Yin Yang 1 under conditions of DNA damage. — Biochem. Biophys. Res. Commun. (2001)
• Satijn D.P.E. et al. The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos. — Mol. Cell. Biol. (2001)