Mouse anti-Human/Mouse sapiens (Human) AKR1B1 Monoclonal Antibody

Function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids and xenobiotics substrates (PubMed:10510318, PubMed:12732097, PubMed:1332968, PubMed:21329684, PubMed:8245005, PubMed:4402695, PubMed:1936586). It catalyzes the reduction of glucose to sorbitol, the first step of the polyol pathway, an alternative route of glucose metabolism that converts glucose to fructose (PubMed:4402695, PubMed:1936586). This pathway becomes highly active under elevated glucose levels, such as during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684)

Subcellular Location

Cytoplasm

Tissue Specificity

Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress

Subunit

Monomer

• Bohren K.M. et al. The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. — J. Biol. Chem. (1989)
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• Graham A. et al. Structure of the human aldose reductase gene. — J. Biol. Chem. (1991)
• Ko B.C.B. et al. Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene. — J. Biol. Chem. (1997)
• Hartmann T.B. et al. SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma. — Br. J. Dermatol. (2004)