Mouse anti-Human/Mouse sapiens (Human) CD48 Monoclonal Antibody

Function

Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation (PubMed:12007789, PubMed:19494291, PubMed:27249817, PubMed:9841922). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex (PubMed:19494291). In turn, promotes LCK phosphorylation and subsequent activation (PubMed:12007789). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (PubMed:27249817)

Subcellular Location

Cell membrane (Lipid-anchor, GPI-anchor); Membrane raft; Secreted

Tissue Specificity

Widely expressed on all hematopoietic cells

Subunit

Interacts with CD2 (PubMed:19494291). Interacts with CD244; this interaction is possible not only on different cells (trans interaction) but also on the same cell (cis interaction) (PubMed:27249817, PubMed:9841922). Interacts with LCK (PubMed:12007789)

• Staunton D.E. et al. Molecular cloning of the lymphocyte activation marker Blast-1. — EMBO J. (1987)
• Vaughan H.A. et al. The isolation of cDNA clones for CD48. — Immunogenetics (1991)
• Korinek V. et al. The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1. — Immunogenetics (1991)
• Kalnine N. et al. Cloning of human full-length CDSs in BD Creator(TM) system donor vector. (OCT-)
• Gregory S.G. et al. The DNA sequence and biological annotation of human chromosome 1. — Nature (2006)
• Mural R.J. et al. PubMed: CI-5GBD0VIIJ7C63 (SEP-)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Fisher R.C. et al. Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48). — Mol. Cell. Biol. (1991)