Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 2
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 3
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 4
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 5
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 6
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 7
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 8
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 9
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 10
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 11
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 12
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 13
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 14
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 15
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 16
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 17
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 18
Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody - Image 19

Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody

Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody — Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth.

SKU: BCREC-000193MA Category:
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Product Specifications

Uniprot No.P14618
Target NamesPKM
Species ReactivityMouse
ImmunogenRecombinant Human Pyruvate kinase PKM protein (2-531AA)
ConjugateNon-conjugated
IsotypeIgG1
ClonalityMonoclonal
ApplicationsELISA, WB, IHC, IF, FC, IP
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth. In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Expressed in adult tissues. Not expressed in tumor cells
Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5

Product Specifications

Mouse anti-Human/Mouse sapiens (Human) PKM Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

Applications: ELISA, WB, IHC, IF, FC, IP

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263)

Subcellular Location

Cytoplasm

Tissue Specificity

Expressed in adult tissues (PubMed:18337823). Not expressed in tumor cells (PubMed:18337823)

Subunit

(Microbial infection) Binding to certain oncoproteins such as HPV-16 E7 oncoprotein promotes homodimerization

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5

Gene: PKM  |  Organism: Homo sapiens  |  Synonyms: Cytosolic thyroid hormone-binding protein; Opa-interacting protein 3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Threonine-protein kinase PKM2; Thyroid hormone-binding protein 1; Tumor M2-PK; Tyrosine-protein kinase PKM2; p58

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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