Mouse anti-Human sapiens (Human) ESR1 Monoclonal Antibody

Mouse anti-Human sapiens (Human) ESR1 Monoclonal Antibody

Mouse anti-Human sapiens (Human) ESR1 Monoclonal Antibody — Involved in activation of NOS3 and endothelial nitric oxide production.

SKU: BCREC-000635MA Category:
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Product Specifications

Uniprot No.P03372
Target NamesESR1
Species ReactivityMouse
ImmunogenSynthesized peptide derived from human Estrogen Receptor α
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
IsotypeIgG2b, Kappa
ClonalityMonoclonal
ApplicationsELISA, IHC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Binds to ERE and inhibits isoform 1.

Biological Context

Subcellular Location: Nucleus; Golgi apparatus; Cell membrane
Tissue Specificity: Widely expressed, however not expressed in the pituitary gland
Disease Association: Estrogen resistance (ESTRR) : A disorder characterized by partial or complete resistance to estrogens, in the presence of elevated estrogen serum levels. Clinical features include absence of the pubertal growth spurt, delayed bone maturation, unfused epiphyses, reduced bone mineral density, osteoporosis, continued growth into adulthood and very tall adult stature. Glucose intolerance, hyperinsulinemia and lipid abnormalities may also be present. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Mouse anti-Human sapiens (Human) ESR1 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

Applications: ELISA, IHC

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861)

Subcellular Location

Nucleus; Golgi apparatus; Cell membrane

Disease Association

Estrogen resistance (ESTRR) : A disorder characterized by partial or complete resistance to estrogens, in the presence of elevated estrogen serum levels. Clinical features include absence of the pubertal growth spurt, delayed bone maturation, unfused epiphyses, reduced bone mineral density, osteoporosis, continued growth into adulthood and very tall adult stature. Glucose intolerance, hyperinsulinemia and lipid abnormalities may also be present. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Widely expressed, however not expressed in the pituitary gland

Subunit

Probably homodimerizes or heterodimerizes with isoform 1 and ESR2

Gene: ESR1  |  Organism: Homo sapiens  |  Synonyms: ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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