Mouse anti-Human sapiens (Human) TRIM34 Monoclonal Antibody
Mouse anti-Human sapiens (Human) TRIM34 Monoclonal Antibody - Image 2
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Mouse anti-Human sapiens (Human) TRIM34 Monoclonal Antibody

Mouse anti-Human sapiens (Human) TRIM34 Monoclonal Antibody — Functions as antiviral protein and contributes to the defense against retroviral infections.

SKU: BCREC-000461MA Category:
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Product Specifications

Uniprot No.Q9BYJ4
Target NamesTRIM34
Species ReactivityMouse
ImmunogenRecombinant Human TRIM34 protein
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
IsotypeMouse IgG2a
ClonalityMonoclonal
ApplicationsELISA, WB, FC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Functions as antiviral protein and contributes to the defense against retroviral infections. Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination.

Biological Context

Subcellular Location: Cytoplasm; Mitochondrion
Tissue Specificity: Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes
Pathway: Protein modification; protein ubiquitination

Product Specifications

Mouse anti-Human sapiens (Human) TRIM34 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

Applications: ELISA, WB, FC

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Functions as antiviral protein and contributes to the defense against retroviral infections (PubMed:17156811, PubMed:32282853). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses (PubMed:32282853). During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination (PubMed:35065966). In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (PubMed:35065966). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis (PubMed:31956709). Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (PubMed:31487507)

Subcellular Location

Cytoplasm; Mitochondrion

Tissue Specificity

Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes

Subunit

(Microbial infection) Interacts (via the B30.2/SPRY domain) with HIV-1 capsid complexes (PubMed:17156811)

Pathway

Protein modification; protein ubiquitination

Gene: TRIM34  |  Organism: Homo sapiens  |  Synonyms: Interferon-responsive finger protein 1; RING finger protein 21
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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