Mouse anti-Human sapiens (Human) TSG101 Monoclonal Antibody
Mouse anti-Human sapiens (Human) TSG101 Monoclonal Antibody - Image 2
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Mouse anti-Human sapiens (Human) TSG101 Monoclonal Antibody

Mouse anti-Human sapiens (Human) TSG101 Monoclonal Antibody — Component of the ESCRT-I complex, a regulator of vesicular trafficking process.

SKU: BCREC-000810MA Category:
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Product Specifications

Uniprot No.Q99816
Target NamesTSG101
Species ReactivityMouse
ImmunogenRecombinant Human TSG101 protein (1-145AA)
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
IsotypeIgG1
ClonalityMonoclonal
ApplicationsELISA, WB, IF, FC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex.

Biological Context

Subcellular Location: Cytoplasm; Early endosome membrane (Peripheral membrane protein); Late endosome membrane (Peripheral membrane protein); Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Midbody, Midbody ring; Nucleus
Tissue Specificity: Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas

Product Specifications

Mouse anti-Human sapiens (Human) TSG101 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426)

Subcellular Location

Cytoplasm; Early endosome membrane (Peripheral membrane protein); Late endosome membrane (Peripheral membrane protein); Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Midbody, Midbody ring; Nucleus

Tissue Specificity

Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas

Subunit

(Microbial infection) Interacts with hepatitis E virus protein ORF3

Gene: TSG101  |  Organism: Homo sapiens  |  Synonyms: ESCRT-I complex subunit TSG101
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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