Mouse anti-Human XRCC4 Monoclonal Antibody
Mouse anti-Human XRCC4 Monoclonal Antibody - Image 2

Mouse anti-Human XRCC4 Monoclonal Antibody

Mouse anti-Human XRCC4 Monoclonal Antibody — Acts as an activator of the phospholipid scramblase activity of XKR4.

SKU: BCREC-000058MA Category:
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Product Specifications

Uniprot No.Q13426
Target NamesXRCC4
Species ReactivityMouse
ImmunogenSynthetic Peptide
ConjugateNon-conjugated
IsotypeIgG
ClonalityMonoclonal
ApplicationsELISA,WB,IP
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Acts as an activator of the phospholipid scramblase activity of XKR4. This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Widely expressed
Disease Association: Short stature, microcephaly, and endocrine dysfunction (SSMED) : A disease characterized by short stature and microcephaly apparent at birth, progressive postnatal growth failure, and endocrine dysfunction. In affected adults endocrine features include hypergonadotropic hypogonadism, multinodular goiter, and diabetes mellitus. Variable features observed in some patients are progressive ataxia, and lymphopenia or borderline leukopenia. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Mouse anti-Human XRCC4 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

Applications: ELISA,WB,IP

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486)

Subcellular Location

Cytoplasm

Disease Association

Short stature, microcephaly, and endocrine dysfunction (SSMED) : A disease characterized by short stature and microcephaly apparent at birth, progressive postnatal growth failure, and endocrine dysfunction. In affected adults endocrine features include hypergonadotropic hypogonadism, multinodular goiter, and diabetes mellitus. Variable features observed in some patients are progressive ataxia, and lymphopenia or borderline leukopenia. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Widely expressed

Subunit

Interacts with XKR4; interacts with the processed form of XKR4, which is cleaved by caspase

Gene: XRCC4  |  Organism: Homo sapiens  |  Synonyms: X-ray repair cross-complementing protein 4

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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