Recombinant Aggregatibacter actinomycetemcomitans Leukotoxin (ltxA), partial, Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans), Yeast, N-terminal 6xHis-tagged, 38.3kDa, purity >85% as determined by SDS-PAGE.

Recombinant Aggregatibacter actinomycetemcomitans Leukotoxin (ltxA), partial

Recombinant Aggregatibacter actinomycetemcomitans Leukotoxin (ltxA), partial — Virulence factor that plays an important role in immune evasion. Purity >85%.

SKU: BCRECP-003312 Category:
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Product Specifications

Product SkuBCRECP-003312
Product DescriptionRecombinant Aggregatibacter actinomycetemcomitans Leukotoxin (ltxA) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 721-1055aa. [Accession | P16462].
Uniprot No.P16462
Gene NamesltxA
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region721-1055aa
SpeciesAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Tag InfoN-terminal 6xHis-tagged
Molecular weight38.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts.

Biological Context

Subcellular Location: Cell outer membrane (Peripheral membrane protein); Secreted

Product Specifications

Recombinant Aggregatibacter actinomycetemcomitans Leukotoxin (ltxA), partial is a recombinant protein from Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans), expressed in Yeast, covering amino acids 721-1055aa, with N-terminal 6xHis-tagged tag, molecular weight 38.3kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Also shows beta-hemolytic activity on certain types of growth media

Subcellular Location

Cell outer membrane (Peripheral membrane protein); Secreted

Subunit

Interacts specifically with the superoxide dismutase [Cu-Zn]. This interaction may protect LtxA from reactive oxygen species and reactive nitrogen species produced by host inflammatory cells during disease (PubMed:17635874). Interacts with the human leukocyte adhesion glycoprotein LFA-1 (ITGAL-ITGB2) (PubMed:17635865)

Gene: ltxA  |  Organism: Aggregatibacter actinomycetemcomitans
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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