Recombinant BK polyomavirus Small t antigen, BK polyomavirus (strain AS) (BKPyV), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 27.9kDa, purity >90% as determined by SDS-PAGE.
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Recombinant BK polyomavirus Small t antigen

Recombinant BK polyomavirus Small t antigen — Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Purity >90%.

SKU: BCRECP-003603 Categories: ,
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Product Specifications

Product SkuBCRECP-003603
Product DescriptionRecombinant BK polyomavirus Small t antigen Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1-172aa. [Accession | P15000].
Uniprot No.P15000
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-172aa
SpeciesBK polyomavirus (strain AS) (BKPyV)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight27.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters.

Biological Context

Subcellular Location: Host cytoplasm; Host nucleus

Product Specifications

Recombinant BK polyomavirus Small t antigen is a recombinant protein from BK polyomavirus (strain AS) (BKPyV), expressed in E.coli, covering amino acids 1-172aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 27.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters. Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation. May establish and maintain high levels of viral genomes during persistent infection in cell culture

Subcellular Location

Host cytoplasm; Host nucleus

Subunit

Interacts with host PPP2R1A; the interaction inhibits PP2A activity

Organism: BK polyomavirus (strain AS)

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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