Recombinant Bovine Splicing factor 3B subunit 3 (SF3B3), partial, Bos taurus (Bovine), E.coli, N-terminal 6xHis-tagged, 42.6kDa, purity >85% as determined by SDS-PAGE.

Recombinant Bovine Splicing factor 3B subunit 3 (SF3B3), partial

Recombinant Bovine Splicing factor 3B subunit 3 (SF3B3), partial — Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. Purity >85%.

SKU: BCRECP-004407 Category:
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Product Specifications

Product SkuBCRECP-004407
Product DescriptionRecombinant Bovine Splicing factor 3B subunit 3 (SF3B3) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 860-1186aa. [Accession | A0JN52].
Uniprot No.A0JN52
Gene NamesSF3B3
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region860-1186aa
SpeciesBos taurus (Bovine)
Tag InfoN-terminal 6xHis-tagged
Molecular weight42.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B3 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA.

Product Specifications

Recombinant Bovine Splicing factor 3B subunit 3 (SF3B3), partial is a recombinant protein, expressed in E.coli, covering amino acids 860-1186aa, with N-terminal 6xHis-tagged tag, molecular weight 42.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B3 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs

Gene: SF3B3  |  Organism: Bos taurus

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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