Recombinant Caenorhabditis elegans Dauer larva development regulatory growth factor daf-7 (daf-7), Caenorhabditis elegans, E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 18.1kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Caenorhabditis elegans Dauer larva development regulatory growth factor daf-7 (daf-7)

Recombinant Caenorhabditis elegans Dauer larva development regulatory growth factor daf-7 (daf-7) — Under harsh environmental conditions, larvae enter a developmentally arrested state known as dauer; TGF-beta-like daf-7 acts to inhibit dauer larva formation and promote growth. Purity >90%.

SKU: BCRECP-002503 Categories: ,
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Product Specifications

Product SkuBCRECP-002503
Product DescriptionRecombinant Caenorhabditis elegans Dauer larva development regulatory growth factor daf-7 (daf-7) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 235-350aa. [Accession | P92172].
Uniprot No.P92172
Gene Namesdaf-7
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region235-350aa
SpeciesCaenorhabditis elegans
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight18.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Under harsh environmental conditions, larvae enter a developmentally arrested state known as dauer; TGF-beta-like daf-7 acts to inhibit dauer larva formation and promote growth. May be a ligand to cell surface receptor daf-4. May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed in the chemosensory neurons, including in the ASJ neurons in males. Expressed in the ASI neurons

Product Specifications

Recombinant Caenorhabditis elegans Dauer larva development regulatory growth factor daf-7 (daf-7) is a recombinant protein from Caenorhabditis elegans, expressed in E.coli, covering amino acids 235-350aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 18.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Under harsh environmental conditions, larvae enter a developmentally arrested state known as dauer; TGF-beta-like daf-7 acts to inhibit dauer larva formation and promote growth (PubMed:37060828, PubMed:8910282). May be a ligand to cell surface receptor daf-4 (PubMed:8413626). May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons (PubMed:8910282). Involved in sensitivity to CO2 levels (PubMed:18524955). Involved in mate searching behavior of males, acting in concert with the neuropeptide pdf-1 (PubMed:30024377). In AWC neurons, acts to promote expression of srsx-3, a member of the GPCR family (PubMed:20713521)

Subcellular Location

Secreted

Tissue Specificity

Expressed in the chemosensory neurons, including in the ASJ neurons in males. Expressed in the ASI neurons (PubMed:37060828)

Gene: daf-7  |  Organism: Caenorhabditis elegans  |  Synonyms: Abnormal dauer formation protein 7
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

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Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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