Recombinant Calloselasma rhodostoma Snaclec rhodocytin subunit beta, Calloselasma rhodostoma (Malayan pit viper) (Agkistrodon rhodostoma), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 21.8kDa, purity >85% as determined by SDS-PAGE.

Recombinant Calloselasma rhodostoma Snaclec rhodocytin subunit beta

Recombinant Calloselasma rhodostoma Snaclec rhodocytin subunit beta — Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Purity >85%.

SKU: BCRECP-003764 Category:
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Product Specifications

Product SkuBCRECP-003764
Product DescriptionRecombinant Calloselasma rhodostoma Snaclec rhodocytin subunit beta Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 24-146aa. [Accession | Q9I840].
Uniprot No.Q9I840
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region24-146aa
SpeciesCalloselasma rhodostoma (Malayan pit viper) (Agkistrodon rhodostoma)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight21.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLCgamma2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed by the venom gland

Product Specifications

Recombinant Calloselasma rhodostoma Snaclec rhodocytin subunit beta is a recombinant protein from Calloselasma rhodostoma (Malayan pit viper) (Agkistrodon rhodostoma), expressed in E.coli, covering amino acids 24-146aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 21.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLCgamma2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial

Subcellular Location

Secreted

Tissue Specificity

Expressed by the venom gland

Subunit

Dimer (non-covalently linked) of heterodimers of subunits alpha and beta (disulfide-linked)

Organism: Calloselasma rhodostoma  |  Synonyms: Aggretin beta chain; Rhodoaggretin subunit beta
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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