Function
Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence factors and host inflammatory responses when protective immunity is absent.
Biological Context
Subcellular Location: Secreted, cell wall; Membrane (Lipid-anchor, GPI-anchor)
Product Specifications
Recombinant Candida albicans Hyphal wall protein 1 (HWP1), partial is a recombinant protein from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast), expressed in E.coli, covering amino acids 27-203aa, with N-terminal 6xHis-tagged tag, molecular weight 24.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
