Recombinant Chicken Indian hedgehog protein (IHH), Gallus gallus (Chicken), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 47.5kDa, purity >90% as determined by SDS-PAGE.

Recombinant Chicken Indian hedgehog protein (IHH)

Recombinant Chicken Indian hedgehog protein (IHH) — The dually lipidated indian hedgehog protein N-product is a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development. Purity >90%.

SKU: BCRECP-003099 Category:
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Product Specifications

Product SkuBCRECP-003099
Product DescriptionRecombinant Chicken Indian hedgehog protein (IHH) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 24-408aa. [Accession | Q98938].
Uniprot No.Q98938
Gene NamesIHH
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region24-408aa
SpeciesGallus gallus (Chicken)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight47.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

The dually lipidated indian hedgehog protein N-product is a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development. Acts by binding to the patched receptor (PTCH1 or PTCH2), relieving smoothened (SMO) inhibition by patched, activating the smoothened signaling pathway and transcription of target genes. In the absence of IHH, patched represses the constitutive signaling activity of SMO.

Biological Context

Subcellular Location: Secreted; Cell membrane (Lipid-anchor)
Tissue Specificity: Expressed in developing midgut, lung and cartilage of developing long bones in the limb

Product Specifications

Recombinant Chicken Indian hedgehog protein (IHH) is a recombinant protein from Gallus gallus (Chicken), expressed in E.coli, covering amino acids 24-408aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 47.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

The dually lipidated indian hedgehog protein N-product is a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development (PubMed:8662546). Acts by binding to the patched receptor (PTCH1 or PTCH2), relieving smoothened (SMO) inhibition by patched, activating the smoothened signaling pathway and transcription of target genes (By similarity). In the absence of IHH, patched represses the constitutive signaling activity of SMO (By similarity). Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton (PubMed:8662546). Positively regulates PTHLH expression during endochondral bone formation preventing chondrocyte hypertrophy (PubMed:8662546). In contrast, participates in normal chondrocyte proliferation in a PTHLH-independent pathway (PubMed:8662546)

Subcellular Location

Secreted; Cell membrane (Lipid-anchor)

Tissue Specificity

Expressed in developing midgut, lung and cartilage of developing long bones in the limb

Subunit

Interacts with BOC and CDON. Interacts with PTCH1 (By similarity). Interacts with glypican GPC3 (By similarity)

Gene: IHH  |  Organism: Gallus gallus

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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