Recombinant Conus striatus Con-ikot-ikot, Conus striatus (Striated cone), E.coli, N-terminal 6xHis-tagged, 13.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Conus striatus Con-ikot-ikot

Recombinant Conus striatus Con-ikot-ikot — Potently and selectively blocks the desensitization of ionotropic glutamate AMPA receptors (GRIA1, GRIA2, GRIA3 and GRIA4). Purity >90%.

SKU: BCRECP-003579 Category:
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Product Specifications

Product SkuBCRECP-003579
Product DescriptionRecombinant Conus striatus Con-ikot-ikot Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 38-123aa. [Accession | P0CB20].
Uniprot No.P0CB20
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region38-123aa
SpeciesConus striatus (Striated cone)
Tag InfoN-terminal 6xHis-tagged
Molecular weight13.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Potently and selectively blocks the desensitization of ionotropic glutamate AMPA receptors (GRIA1, GRIA2, GRIA3 and GRIA4). Binds to a different site than does the drug cyclothiazide. The toxin acts like a straitjacket on the 'gating ring' of the ligand-binding domain (LBD) of the receptor.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed by the venom duct

Product Specifications

Recombinant Conus striatus Con-ikot-ikot is a recombinant protein from Conus striatus (Striated cone), expressed in E.coli, covering amino acids 38-123aa, with N-terminal 6xHis-tagged tag, molecular weight 13.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Potently and selectively blocks the desensitization of ionotropic glutamate AMPA receptors (GRIA1, GRIA2, GRIA3 and GRIA4) (PubMed:19481459, PubMed:35377397). Binds to a different site than does the drug cyclothiazide (PubMed:19481459). The toxin acts like a straitjacket on the 'gating ring' of the ligand-binding domain (LBD) of the receptor (PubMed:25103405). It does so by restraining the domains via both intra- and interdimer cross-links such that agonist-induced closure of the LBD 'clamshells' is transduced into an irislike expansion of the gating ring (PubMed:25103405). Compared to other desensitization blockers, it is a poor stabilizer of the open channel because toxin-bound AMPA receptors undergo frequent brief closures (PubMed:35377397). In vitro, application of the toxin to hippocampal slices causes a large and rapid increase in resting AMPA receptor-mediated current leading to neuronal death (PubMed:19481459)

Subcellular Location

Secreted

Tissue Specificity

Expressed by the venom duct

Subunit

Homodimer; disulfide-linked

Organism: Conus striatus

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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