Recombinant Dendroaspis angusticeps Natriuretic peptide DNP, Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps), E.coli, N-terminal 6xHis-KSI-tagged, 19.5kDa, purity >85% as determined by SDS-PAGE.

Recombinant Dendroaspis angusticeps Natriuretic peptide DNP

Recombinant Dendroaspis angusticeps Natriuretic peptide DNP — Exhibits vasodilator, natriuretic and diuretic properties in animal models and human tissues. Purity >85%.

SKU: BCRECP-003621 Category:
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Product Specifications

Product SkuBCRECP-003621
Product DescriptionRecombinant Dendroaspis angusticeps Natriuretic peptide DNP Protein is expressed from E.coli with N-terminal 6xHis-KSI-tagged. It contains 1-38aa. [Accession | P28374].
Uniprot No.P28374
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-38aa
SpeciesDendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Tag InfoN-terminal 6xHis-KSI-tagged
Molecular weight19.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Exhibits vasodilator, natriuretic and diuretic properties in animal models and human tissues. Acts by stimulating cGMP via the natriuretic peptide receptor 1 (NPR1). Is a poor agonist of the atrial natriuretic peptide receptor 2 (NPR2).

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed by the venom gland

Product Specifications

Recombinant Dendroaspis angusticeps Natriuretic peptide DNP is a recombinant protein from Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps), expressed in E.coli, covering amino acids 1-38aa, with N-terminal 6xHis-KSI-tagged tag, molecular weight 19.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Exhibits vasodilator, natriuretic and diuretic properties in animal models and human tissues. Acts by stimulating cGMP via the natriuretic peptide receptor 1 (NPR1) (PubMed:16778132). Is a poor agonist of the atrial natriuretic peptide receptor 2 (NPR2). Is not degraded by neutral endopeptidase (NEP/MME). Binds to atrial natriuretic peptide clearance receptor (NPR-C/NPR3), which may be responsible of the removal of DNP from the circulation (PubMed:17475216). Increases calcium uptake and induces histamine release from rat peritoneal mast cells. Increases calcium-activated potassium (KCa) current in gastric antral circular smooth muscle cells by increasing cGMP production and activating inositol trisphosphate receptors (IP3Rs) (PubMed:18096107). In vivo, reduces both systolic and diastolic blood pressure with no effect on heart rate, when intravenously injected in conscious rabbits (PubMed:37049825)

Subcellular Location

Secreted

Tissue Specificity

Expressed by the venom gland

Organism: Dendroaspis angusticeps
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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