Recombinant Dog Angiopoietin-2 (ANGPT2) (Active), Canis lupus familiaris (Dog) (Canis familiaris), Mammalian cell, C-terminal 6xHis-tagged, 57.2 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Dog Angiopoietin-2 (ANGPT2) (Active)

Recombinant Dog Angiopoietin-2 (ANGPT2) (Active) — Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Purity >95%.

SKU: BCACP-000187 Category:
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Product SKUBCACP-000187
Product DescriptionRecombinant Canis familiaris Angiopoietin-2 (ANGPT2) protein is expressed from Mammalian cell with C-terminal 6xHis-tagged. It contains 19-495aa. [Accession | A0A8J8].
Uniprot No.A0A8J8
Gene NamesANGPT2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region19-495aa
SpeciesCanis lupus familiaris (Dog) (Canis familiaris)
Tag InfoC-terminal 6xHis-tagged
Molecular weight57.2 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human ENPP3 at 2 μg/mL can bind anti-ENPP3 recombinant antibody , the EC50 is 2.151-2.492 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(ANG-2)

Function

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression.

Product Specifications

Recombinant Dog Angiopoietin-2 (ANGPT2) (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 19-495aa, with C-terminal 6xHis-tagged tag, molecular weight 57.2 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ENPP3 at 2 μg/mL can bind anti-ENPP3 recombinant antibody , the EC50 is 2.151-2.492 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (By similarity). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (By similarity). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression (By similarity). In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). Involved in the regulation of lymphangiogenesis (By similarity)

Gene: ANGPT2  |  Organism: Canis lupus familiaris

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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