Recombinant Dog CD274 molecule (CD274), partial, Canis lupus familiaris (Dog) (Canis familiaris), Mammalian cell, C-terminal 10xHis-tagged, 26.2kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Dog CD274 molecule (CD274), partial

Recombinant Dog CD274 molecule (CD274), partial — The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. Purity >95%.

SKU: BCRECP-002316 Categories: ,
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Product Specifications

Product SkuBCRECP-002316
Product DescriptionRecombinant Dog CD274 molecule (CD274) Protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 19-236aa. [Accession | E2RKZ5].
Uniprot No.E2RKZ5
Gene NamesCD274
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region19-236aa
SpeciesCanis lupus familiaris (Dog) (Canis familiaris)
Tag InfoC-terminal 10xHis-tagged
Molecular weight26.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein); Early endosome membrane (Single-pass type I membrane protein); Recycling endosome membrane (Single-pass type I membrane protein)

Product Specifications

Recombinant Dog CD274 molecule (CD274), partial is a recombinant protein from Canis lupus familiaris (Dog) (Canis familiaris), expressed in Mammalian cell, covering amino acids 19-236aa, with C-terminal 10xHis-tagged tag, molecular weight 26.2kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Early endosome membrane (Single-pass type I membrane protein); Recycling endosome membrane (Single-pass type I membrane protein)

Gene: PDL1  |  Organism: Canis lupus familiaris  |  Synonyms: B7 homolog 1

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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