Recombinant Dog Erythropoietin receptor (EPOR), partial — recombinant protein from Canis lupus familiaris (Dog) (Canis familiaris), expressed in E.coli. Purity >85%.
| Product Sku | BCRECP-002646 |
| Product Description | Recombinant Dog Erythropoietin receptor (EPOR) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 25-250aa. [Accession | Q2KL21]. |
| Uniprot No. | Q2KL21 |
| Gene Names | EPOR |
| Purity | Greater than 85% as determined by SDS-PAGE. |
| Expression System | E.coli |
| Expression Region | 25-250aa |
| Species | Canis lupus familiaris (Dog) (Canis familiaris) |
| Tag Info | C-terminal 6xHis-tagged |
| Molecular weight | 25.5kDa |
| Activity | Please contact us to obtain bioactivity data. |
| Buffer | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose. |
| Storage | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| Research Areas | Cardiovascular |
Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
Recombinant Dog Erythropoietin receptor (EPOR), partial — recombinant protein from Canis lupus familiaris (Dog) (Canis familiaris), expressed in E.coli. Purity >85%. Suitable for ELISA and Western Blot applications.
Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.
Biological Activity: Please contact us to obtain bioactivity data.
Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.
Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling
Cell membrane (Single-pass type I membrane protein)
Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein SH2B2, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3, CRKL (By similarity). Interacts with INPP5D/SHIP1 (By similarity). SH2B2 binding inhibits the JAK-STAT signaling. Interacts with RHEX; this interaction occurs in a erythropoietin (EPO)-dependent manner. Interacts with ATXN2L (By similarity)
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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.
Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.
Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.
