Recombinant Drosophila melanogaster Sterile alpha and TIR motif-containing protein 1 (Ect4), partial, Drosophila melanogaster (Fruit fly), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 41.7kDa, purity >85% as determined by SDS-PAGE.

Recombinant Drosophila melanogaster Sterile alpha and TIR motif-containing protein 1 (Ect4), partial

Recombinant Drosophila melanogaster Sterile alpha and TIR motif-containing protein 1 (Ect4), partial — NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Purity >85%.

SKU: BCRECP-002587 Category:
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Product Specifications

Product SkuBCRECP-002587
Product DescriptionRecombinant Drosophila melanogaster Sterile alpha and TIR motif-containing protein 1 (Ect4) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 370-678aa. [Accession | Q6IDD9].
Uniprot No.Q6IDD9
Gene NamesEct4
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region370-678aa
SpeciesDrosophila melanogaster (Fruit fly)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight41.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site.

Product Specifications

Recombinant Drosophila melanogaster Sterile alpha and TIR motif-containing protein 1 (Ect4), partial — NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Purity >85%. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:22678360, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:22678360). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, it is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting axon destruction (PubMed:22678360, PubMed:28334607, PubMed:31439792). Involved in the down-regulation of the tracheal immune response to Gram-negative bacteria (PubMed:22022271). This is likely by mediating Tollo signaling in the tracheal epithelium (PubMed:22022271)

Subcellular Location

Cytoplasm; Cell projection, axon

Tissue Specificity

Widely expressed in larval brains and adult brains

Gene: Sarm  |  Organism: Drosophila melanogaster  |  Synonyms: Sterile alpha and TIR motif-containing protein 1; Tir-1 homolog
Key Publications

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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