Recombinant Echis carinatus Zinc metalloproteinase-disintegrin-like ecarin, Echis carinatus (Saw-scaled viper), E.coli, N-terminal 6xHis-SUMO-tagged, 60.8kDa, purity >90% as determined by SDS-PAGE.

Recombinant Echis carinatus Zinc metalloproteinase-disintegrin-like ecarin

Recombinant Echis carinatus Zinc metalloproteinase-disintegrin-like ecarin — Snake venom zinc metalloproteinase that catalyzes the conversion of prothrombin (F2) to alpha-thrombin through formation of a thrombin intermediate, thereby functioning as a procoagulant protein. Purity >90%.

SKU: BCRECP-003755 Category:
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Product Specifications

Product SkuBCRECP-003755
Product DescriptionRecombinant Echis carinatus Zinc metalloproteinase-disintegrin-like ecarin Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 191-616aa. [Accession | Q90495].
Uniprot No.Q90495
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region191-616aa
SpeciesEchis carinatus (Saw-scaled viper)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight60.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Snake venom zinc metalloproteinase that catalyzes the conversion of prothrombin (F2) to alpha-thrombin through formation of a thrombin intermediate, thereby functioning as a procoagulant protein. Has a low Km for prothrombin and a high kcat. Cleaves the 320-Arg-Ile-321 bond in prothrombin and produces meizothrombin which is ultimately converted to alpha-thrombin by autolysis.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed by the venom gland

Product Specifications

Recombinant Echis carinatus Zinc metalloproteinase-disintegrin-like ecarin is a recombinant protein from Echis carinatus (Saw-scaled viper), expressed in E.coli, covering amino acids 191-616aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 60.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Snake venom zinc metalloproteinase that catalyzes the conversion of prothrombin (F2) to alpha-thrombin through formation of a thrombin intermediate, thereby functioning as a procoagulant protein (PubMed:39195771, PubMed:956136). Has a low Km for prothrombin and a high kcat (PubMed:39195771, PubMed:956136). Cleaves the 320-Arg-Ile-321 bond in prothrombin and produces meizothrombin which is ultimately converted to alpha-thrombin by autolysis (PubMed:956136)

Subcellular Location

Secreted

Tissue Specificity

Expressed by the venom gland

Subunit

Monomer

Organism: Echis carinatus  |  Synonyms: Snake venom metalloproteinase

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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