Recombinant Epstein-Barr virus Latent membrane protein 1 (LMP1), partial, Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4), E.coli, N-terminal 6xHis-taggedand C-terminal Myc-tagged, 28.2kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Epstein-Barr virus Latent membrane protein 1 (LMP1), partial

Recombinant Epstein-Barr virus Latent membrane protein 1 (LMP1), partial — Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Purity >85%.

SKU: BCRECP-003273 Categories: ,
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Product Specifications

Product SkuBCRECP-003273
Product DescriptionRecombinant Epstein-Barr virus Latent membrane protein 1 (LMP1) Protein is expressed from E.coli with N-terminal 6xHis-taggedand C-terminal Myc-tagged. It contains 185-386aa. [Accession | P03230].
Uniprot No.P03230
Gene NamesLMP1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region185-386aa
SpeciesEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Tag InfoN-terminal 6xHis-taggedand C-terminal Myc-tagged
Molecular weight28.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells.

Biological Context

Subcellular Location: Host cell membrane (Multi-pass membrane protein)

Product Specifications

Recombinant Epstein-Barr virus Latent membrane protein 1 (LMP1), partial is a recombinant protein from Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4), expressed in E.coli, covering amino acids 185-386aa, with N-terminal 6xHis-taggedand C-terminal Myc-tagged tag, molecular weight 28.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family (PubMed:25996949). LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. Also inhibits host IFN-alpha-stimulated STAT2 nuclear translocation and interferon-stimulated response element transcriptional activity by interacting with and inhibiting host TYK2. Induces SUMO expression during viral latency thereby dysregulating the host sumoylation processes (PubMed:30659232)

Subcellular Location

Host cell membrane (Multi-pass membrane protein)

Subunit

Interacts (via PXQXT motif) with host tumor necrosis factor receptor-associated factor (TRAF) proteins TRAF1, TRAF2, TRAF3 and TRAF5 (PubMed:25996949). Interacts with human protein ZMYND11; leading to negatively regulate NF-kappa-B activation. Interacts with host UBE2I; this interaction induces the sumoylation of various cellular proteins (PubMed:21795333). Interacts with host IRF7. Interacts with host TYK2

Gene: LMP1  |  Organism: Epstein-Barr virus (strain B95-8)  |  Synonyms: Protein p63
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

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Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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