Recombinant Escherichia coli Lipopolysaccharide assembly protein B (lapB), partial, Escherichia coli (strain K12), E.coli, N-terminal 6xHis-SUMO-tagged, 58.8kDa, purity >90% as determined by SDS-PAGE.

Recombinant Escherichia coli Lipopolysaccharide assembly protein B (lapB), partial

Recombinant Escherichia coli Lipopolysaccharide assembly protein B (lapB), partial — Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. Purity >90%.

SKU: BCRECP-003240 Category:
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Product Specifications

Product SkuBCRECP-003240
Product DescriptionRecombinant Escherichia coli Lipopolysaccharide assembly protein B (lapB) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 17-389aa. [Accession | P0AB58].
Uniprot No.P0AB58
Gene NameslapB
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region17-389aa
SpeciesEscherichia coli (strain K12)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight58.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. Regulates the proteolytic activity of FtsH towards LpxC by acting as an adapter protein which interacts with FtsH via its transmembrane helices while its cytoplasmic domain recruits LpxC for degradation by FtsH. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

Biological Context

Subcellular Location: Cell inner membrane (Single-pass membrane protein)

Product Specifications

Recombinant Escherichia coli Lipopolysaccharide assembly protein B (lapB), partial is a recombinant protein from Escherichia coli (strain K12), expressed in E.coli, covering amino acids 17-389aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 58.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. Regulates the proteolytic activity of FtsH towards LpxC by acting as an adapter protein which interacts with FtsH via its transmembrane helices while its cytoplasmic domain recruits LpxC for degradation by FtsH. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane

Subcellular Location

Cell inner membrane (Single-pass membrane protein)

Subunit

Forms a heterotetramer with PbgA/YjeM consisting of 2 molecules of LapB and 2 molecules of PbgA; the complex dissociates when excess lipopolysaccharide (LPS) accumulates in the inner membrane due to overlapping binding sites for LPS and LapB on PbgA (PubMed:32430473, PubMed:32788728, PubMed:33260377, PubMed:35931690). Interacts with FtsH; the interaction promotes FtsH-mediated proteolysis of LpxC (PubMed:35931690)

Gene: lapB  |  Organism: Escherichia coli (strain K12)  |  Synonyms: Lipopolysaccharide regulatory protein; LpxC degradation adapter protein B
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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